THE RESEARCH
10 years of INSERM - INM partnership
Biolux expertise
From research to people
4 fundamental axes
Various investigations have highlighted the role of photomodulation in cell migration, proliferation and differentiation as well as in the regulation of inflammation.
Published article: Validation of the action of LEDs on the neuritic growth velocity of sensory neurons : under axotomy conditions, the neuritic growth velocity obtained after LED stimulation reached a threshold never equaled in the articles available in the literature.
Transition before the application of stimulation protocols in the clinic; the investigations set up have made it possible to validate on more integrated models, the various results obtained at the cellular scale.
Transfer of knowledge and technology in therapeutic application: creation of professional and home care devices for clinical use.
An international clinical study in collaboration with a Brazilian team has been set up to evaluate the effect of photomodulation on the scars induced by abdominoplasty. This study definitively validates the effect of Biolux technology on the 4 areas of research, all involved in the post-surgical healing process.
A constant investment
Continuous improvement and innovation of therapeutic possibilities commits Biolux to continuing to invest in R&D :
✓ by developing new academic and private partnerships (collaboration with renowned doctors and clinics)
✓ by relying on the multidisciplinary nature of its R&D team
✓ by offering new functionalities of evolving and ever more innovative devices.
Bibliographic references photomodulation
Basic research (non-exhaustive list)
- Burland, M, Paris L. et al. (2014), Neurite growth acceleration of adult Dorsal Root Ganglion neurons illuminated by low-level Light Emitting Diode light at 645 nm; J. Biophotonics 1-9 (2014)/DOI 10.1002/jbio.201400052
- Basha A. A et al (2016) Effect of LED photobiomodulation on fluorescent light induced changes in cellular ATPases and Cytochrome c oxidase activity in Wistar rat; J Drugs Dermatol. 2016 Jul 1;15(7):843-8.
- Silveira PC et al. (2016) Effect of Low-Power Laser (LPL) and Light-Emitting Diode (LED) on Inflammatory Response in Burn Wound Healing; Inflammation. 2016 Aug;39(4):1395-404. doi:10.1007/s10753-016-0371-x.
- Lee WJ et al. (2016) Efficacy of Red or Infrared Light-Emitting Diodes in a Mouse Model of Propionibacterium acnes-Induced Inflammation; Ann Dermatol. 2016 Apr;28(2):186-91. doi: 10.5021/ad.2016.28.2.186. Epub 2016 Mar 31.
- Leite SN et al. (2014) Phototherapy promotes healing of cutaneous wounds in undernourished rats; An Bras Dermatol. 2014 Nov-Dec;89(6):899-904.
- Spitler Ret al. (2014) Comparison of laser and diode sources for acceleration of in vitro wound healing by low-level light therapy; J Biomed Opt. 2014 Mar;19(3):38001. doi: 10.1117/1.JBO.19.3.038001.
- Piva, JA d. AC (2011) Effect of low-level laser therapy on the initial stages of tissue repair: basic principles; Anais Brasileiros of Dermatology.
- Huang, YY, AC Chen, et al. (2011). Biphasic dose response in low level light therapy – an update; Dose Response. 2011;9(4):602-18. doi: 10.2203/dose-response.11-009.Hamblin. Epub 2011 Sep 2.
- Huang, YY, AC Chen, et al. (2009). Biphasic dose response in low level light therapy; Dose Response 2009 Sep 1;7(4):358-83. doi:10.2203/dose-response.09-027.Hamblin.
- Albertini, R., AB Villaverde, et al. (2007). “Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660 nm and 684 nm) in carrageenan-induced rat paw edema. » J Photochem Photobiol B 89(1): 50-55.
Clinical investigations (non-exhaustive list)
LEDs & Soft Peels _ Evaluation of the complementarity of two technologies to fight against skin aging, Dr. Jean-Luc Vigneron. Results presented at SECLARM, Geneva, in 2014
Yoo KH et al. (2015) Efficacy of combination light-emitting diode (635 and 830 nm) therapy in treating local injection-site reactions after filler; Clin Exp Dermatol. 2015 Apr;40(3):333-5. doi: 10.1111/ced.12480. Epub 2014 Sep 30.
Calderhead RG et al.(2015) Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures;Thermal Laser.2015 Dec 30;24(4):277-89.doi: 10.5978/islsm.15-OR-17.
Oh IY (2013) Efficacy of light-emitting diode photomodulation in reducing erythema after fractional carbon dioxide laser resurfacing: a pilot study;Dermatol Surg.2013 Aug;39(8):1171-6.doi: 10.1111/dsu.12213.Epub 2013 Apr 3.
Lee, SY, KH Park, et al.(2007).A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings;J Photochem Photobiol B 88(1): 51-67.
