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BioLux

THE RESEARCH


Since its creation in 2007, research and collaboration with experienced researchers has been at the heart of Biolux's DNA.

10 years of INSERM - INM partnership

An exclusive collaboration signed with an INSERM team based at the Montpellier Neuroscience Institute (INM) has enabled Biolux to understand the mechanisms of action of photomodulation.

Biolux expertise

The multidisciplinary expertise of our R&D team has validated the effectiveness of our treatments at different scales.

From research to people

Biolux medical progress begins with fundamental research followed by translational and clinical research to finally be available to humans.
4 fundamental axes
The research and development of photomodulation research programs are based on 4 major axes around which all protocols are developed:
Healing
Inflammation
Regeneration
Pain
In vitro level

Various investigations have highlighted the role of photomodulation in cell migration, proliferation and differentiation as well as in the regulation of inflammation. 

Article published:  Validation of the action of LEDs on the speed of neurite growth of sensory neurons : in axotomy conditions, the speed of neurite growth obtained after LED stimulation has reached a threshold never equaled in the articles available in the literature.

In-vivo level

Transition before the application of stimulation protocols in the clinic; the investigations set up have made it possible to validate on more integrated models, the various results obtained at the cellular scale.

Translational level

Transfer of knowledge and technology in therapeutic application: creation of professional and home care devices for clinical use.

Clinical level

An international clinical study in collaboration with a Brazilian team has been set up to evaluate the effect of photomodulation on the scars induced by abdominoplasty. This study definitively validates the effect of Biolux technology on the 4 areas of research, all involved in the post-surgical healing process.

A constant investment

The continuous improvement and innovation of therapeutic possibilities commits Biolux to continue investing in R&D :

by developing new academic and private partnerships (collaboration with renowned doctors and clinics)
by relying on the multidisciplinarity of its R&D team by offering new functionalities of scalable and ever more innovative devices.

Bibliographic references photomodulation

Basic research (non-exhaustive list)

- Burland, M, Paris L. et al.
(2014), Neurite growth acceleration of adult Dorsal Root Ganglion neurons illuminated by low-level Light Emitting Diode light at 645 nm; J. Biophotonics 1-9 (2014)/DOI 10.1002/jbio.201400052 - Basha A. A et al (2016) Effect of LED photobiomodulation on fluorescent light induced changes in cellular ATPases and Cytochrome c oxidase activity in Wistar rat;
J Drugs Dermatol. 2016 Jul 1;15(7):843-8. - Silveira PC et al.
(2016) Effect of Low-Power Laser (LPL) and Light-Emitting Diode (LED) on Inflammatory Response in Burn Wound Healing; Inflammation. 2016 Aug;39(4):1395-404. doi: 10.1007/s10753-016-0371-x. - Lee WJ et al.
(2016) Efficacy of Red or Infrared Light-Emitting Diodes in a Mouse Model of Propionibacterium acnes-Induced Inflammation; Ann Dermatol. 2016 Apr;28(2):186-91. doi: 10.5021/ad.2016.28.2.186. Epub 2016 Mar 31. - Leite SN et al.
(2014) Phototherapy promotes healing of cutaneous wounds in undernourished rats; An Bras Dermatol. 2014 Nov-Dec;89(6):899-904. - Spitler Ret al.
(2014) Comparison of laser and diode sources for acceleration of in vitro wound healing by low-level light therapy; J Biomed Opt. 2014 Mar;19(3):38001. doi: 10.1117/1.JBO.19.3.038001. - Piva, JA d.
AC (2011) Effect of low-level laser therapy on the initial stages of tissue repair: basic principles; Anais Brasileiros from Dermatologia. - Huang, YY, AC Chen, et al.
(2011). Biphasic dose response in low level light therapy – an update; Dose response. 2011;9(4):602-18. doi: 10.2203/dose-response.11-009.Hamblin. Epub 2011 Sep 2. - Huang, YY, AC Chen, et al.
(2009). Biphasic dose response in low level light therapy; Dose Response 2009 Sep 1;7(4):358-83. doi: 10.2203/dose-response.09-027.Hamblin. - Albertini, R., AB Villaverde, et al. (2007). “Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660 nm and 684 nm) in carrageenan-induced rat paw edema. J Photochem Photobiol B 89(1): 50-55.

Clinical investigations (non-exhaustive list)

LEDs & Soft Peels _ Evaluation of the complementarity of two technologies to fight against skin aging, Dr. Jean-Luc Vigneron. Results presented at SECLARM, Geneva, in 2014

Yoo KH et al. (2015) Efficacy of combination light-emitting diode (635 and 830 nm) therapy in treating local injection-site reactions after filler; Clin Exp Dermatol. 2015 Apr;40(3):333-5. doi: 10.1111/ced.12480. Epub 2014 Sep 30.

Calderhead RG et al.
(2015) Adjunctive 830 nm light-emitting diode therapy can improve the results following aesthetic procedures; Thermal Laser. 2015 Dec 30;24(4):277-89. doi: 10.5978/islsm.15-OR-17. Oh IY (2013) Efficacy of light-emitting diode photomodulation in reducing erythema after fractional carbon dioxide laser resurfacing: a pilot study;
Dermatol Surg. 2013 Aug;39(8):1171-6. doi: 10.1111/dsu.12213. Epub 2013 Apr 3. Lee, SY, KH Park, et al. (2007). A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings; J Photochem Photobiol B 88(1): 51-67.